A comparison of lipid diffusive dynamics in monolayers and bilayers in the context of interleaflet coupling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00600179" target="_blank" >RIV/61388963:_____/25:00600179 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.bbamem.2024.184388" target="_blank" >https://doi.org/10.1016/j.bbamem.2024.184388</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbamem.2024.184388" target="_blank" >10.1016/j.bbamem.2024.184388</a>

Result language
angličtina
Original language name
A comparison of lipid diffusive dynamics in monolayers and bilayers in the context of interleaflet coupling
Original language description
Cellular membranes are composed of lipids typically organized in a double-leaflet structure. Interactions between these two leaflets often referred to as interleaflet coupling play a crucial role in various cellular processes. Despite extensive study, the mechanisms governing such interactions remain incompletely understood. Here, we investigate the effects of interleaflet coupling from a specific point of view, i.e. by comparing diffusive dynamics in bilayers and monolayers, focusing on potential lipid-specific interactions between opposing leaflets. Through quantitative fluorescence microscopy techniques, we characterize lipid diffusion and mean molecular area in monolayers and bilayers composed of different lipids. Our results suggest that the observed decrease in bilayer lipid diffusion compared to monolayers depends on lipid identity. Furthermore, our analysis suggests that lipid acyl chain structure and spatial configuration at the bilayer may strongly influence interleaflet interactions and dynamics in bilayers. These findings provide insights into the role of lipid structure in mediating interleaflet coupling and underscore the need for further experimental investigations to elucidate the underlying mechanisms.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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