pH and Medium Polarity-Induced Self-Assembly of Fmoc-Tryptophan into Multiple Superstructures: An Experimental and Theoretical Investigations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00636153" target="_blank" >RIV/61388963:_____/25:00636153 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/cplu.202500036" target="_blank" >https://doi.org/10.1002/cplu.202500036</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cplu.202500036" target="_blank" >10.1002/cplu.202500036</a>
Alternative languages
Result language
angličtina
Original language name
pH and Medium Polarity-Induced Self-Assembly of Fmoc-Tryptophan into Multiple Superstructures: An Experimental and Theoretical Investigations
Original language description
Self-assembly of functionalized molecular building blocks is an effective and resource-saving bottom-up technique to generate multiple superstructures with various functionality and morphologies. The nature of the molecule and the factors controlling the overall self-assembly process are extremely vital in fundamental aspects of self-assembly, which deliver insights into the fabrication of multiple assemblies with specific functionality. The self-assembly of suitably functionalized amino acids leads to the formation of diverse structures with distinct properties, making them ideal bio-organic scaffolds for various applications. The present study reports, the pH and solvent polarity-induced self-assembly of 9-fluorenylmethoxycarbonyl (Fmoc)-Tryptophan into various self-assembled superstructures with morphological individualities, explore the plausible pathway of morphological transformation of Fmoc-Trp into multiple superstructures having a wide range of well-defined morphologies, including spheres, hollow spheres, nanoflowers, nanosheets, nanorods, and cube-like structures, as characterized through conventional microscopic techniques. Detailed UV-vis, fluorescence, powder X-ray diffraction analysis, and Fourier transform infrared analyses reveal significant insights into the intermolecular interactions, which trigger the overall self-assembly process. The computational studies, including full geometry optimization and molecular dynamics simulations, are conducted to investigate the aggregation properties of modified amino acids (Fmoc-Trp). These studies highlight the crucial role of pi-pi stacking and hydrogen bonding in tuning the overall self-assembly with morphological variation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemPlusChem
ISSN
2192-6506
e-ISSN
2192-6506
Volume of the periodical
90
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
e202500036
UT code for WoS article
001461336400001
EID of the result in the Scopus database
2-s2.0-105002169770