Technologies for Decoding Cancer Metabolism with Spatial Resolution
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00637237" target="_blank" >RIV/61388963:_____/25:00637237 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1101/cshperspect.a041553" target="_blank" >https://doi.org/10.1101/cshperspect.a041553</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1101/cshperspect.a041553" target="_blank" >10.1101/cshperspect.a041553</a>
Alternative languages
Result language
angličtina
Original language name
Technologies for Decoding Cancer Metabolism with Spatial Resolution
Original language description
It is increasingly appreciated that cancer cells adapt their metabolic pathways to support rapid growth and proliferation as well as survival, often even under the poor nutrient conditions that characterize some tumors. Cancer cells can also rewire their metabolism to circumvent chemotherapeutics that inhibit core metabolic pathways, such as nucleotide synthesis. A critical approach to the study of cancer metabolism is metabolite profiling (metabolomics), the set of technologies, usually based on mass spectrometry, that allow for the detection and quantification of metabolites in cancer cells and their environments. Metabolomics is a burgeoning field, driven by technological innovations in mass spectrometers, as well as novel approaches to isolate cells, subcellular compartments, and rare fluids, such as the interstitial fluid of tumors. Here, we discuss three emerging metabolomic technologies: spatial metabolomics, single-cell metabolomics, and organellar metabolomics. The use of these technologies along with more established profiling methods, like single-cell transcriptomics and proteomics, is likely to underlie new discoveries and questions in cancer research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cold Spring Harbor Perspectives in Medicine
ISSN
2157-1422
e-ISSN
2157-1422
Volume of the periodical
15
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
a041553
UT code for WoS article
001520627900001
EID of the result in the Scopus database
2-s2.0-105010032178