Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73610020" target="_blank" >RIV/61989592:15110/22:73610020 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25310/22:39917771
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1388198121002109?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388198121002109?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbalip.2021.159082" target="_blank" >10.1016/j.bbalip.2021.159082</a>
Alternative languages
Result language
angličtina
Original language name
Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues
Original language description
Lung cancer represents one of the leading worldwide causes of cancer death, but the pathobiochemistry of this disease is still not fully understood. Here we characterize the lipidomic and metabolomic profiles of the tumor and surrounding normal tissues for 23 patients with non-small cell lung cancer. In total, 500 molecular species were identified and quantified by a combination of the lipidomic shotgun tandem mass spectrometry (MS/MS) analysis and the targeted metabolomic approach using liquid chromatography (LC) – MS/MS. The statistical evaluation includes multivariate and univariate methods with the emphasis on paired statistical approaches. Our research revealed significant changes in several biochemical pathways related to the central carbon metabolism, acylcarnitines, dipeptides as well as the disruption in the lipid metabolism observed mainly for glycerophospholipids, sphingolipids, and cholesteryl esters.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
—
Continuities
—
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
ISSN
1388-1981
e-ISSN
1879-2618
Volume of the periodical
1867
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
159082
UT code for WoS article
000729063500006
EID of the result in the Scopus database
2-s2.0-85120402480