The effect of HPMA copolymer-bound doxorubicin conjugates on the expression of genes involved in apoptosis signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F03%3A00100370" target="_blank" >RIV/61388971:_____/03:00100370 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The effect of HPMA copolymer-bound doxorubicin conjugates on the expression of genes involved in apoptosis signaling
Original language description
Conjugate containing doxorubicin bound via pH sensitive bond has much higher in vitro cytostatic effect in comparison with conjugates containing doxorubicin bound via enzymaticly degradable bond. Fas and Bax expression is stronger after exposition of 38C13 cells to PHPMA-DoxHYD conjugates, while caspase 8 expression is stronger in PHPMA-DoxAM conjugates.
Czech name
Exprese genů pro signalizaci apoptozy u buněk vystavených účinku HPMA konjugátů doxorubicinu
Czech description
N-(2-hydroxypropyl)metakrylamid nesoucí doxorubicin navázaný prostřednictvím pH senzitivní vazby je v in vitro systému účinější než konjugát s enzymaticky štěpitelnou vazbou mezi doxorubicinem a polymerním nosičem. Hydrolyticky štěpitelný konjugát indukuje expresi pro-apoptotických proteinů Fas a bax.
Classification
Type
D - Article in proceedings
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
International Symposium on Tumor targeted delivery Systems /2./
ISBN
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ISSN
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e-ISSN
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Number of pages
2
Pages from-to
247-248
Publisher name
Neuveden
Place of publication
Maryland
Event location
Maryland
Event date
Sep 23, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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