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The effect of HPMA copolymer-bound doxorubicin conjugates on the expression of genes involved in apoptosis signaling

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F03%3A00100370" target="_blank" >RIV/61388971:_____/03:00100370 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of HPMA copolymer-bound doxorubicin conjugates on the expression of genes involved in apoptosis signaling

  • Original language description

    Conjugate containing doxorubicin bound via pH sensitive bond has much higher in vitro cytostatic effect in comparison with conjugates containing doxorubicin bound via enzymaticly degradable bond. Fas and Bax expression is stronger after exposition of 38C13 cells to PHPMA-DoxHYD conjugates, while caspase 8 expression is stronger in PHPMA-DoxAM conjugates.

  • Czech name

    Exprese genů pro signalizaci apoptozy u buněk vystavených účinku HPMA konjugátů doxorubicinu

  • Czech description

    N-(2-hydroxypropyl)metakrylamid nesoucí doxorubicin navázaný prostřednictvím pH senzitivní vazby je v in vitro systému účinější než konjugát s enzymaticky štěpitelnou vazbou mezi doxorubicinem a polymerním nosičem. Hydrolyticky štěpitelný konjugát indukuje expresi pro-apoptotických proteinů Fas a bax.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    International Symposium on Tumor targeted delivery Systems /2./

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    2

  • Pages from-to

    247-248

  • Publisher name

    Neuveden

  • Place of publication

    Maryland

  • Event location

    Maryland

  • Event date

    Sep 23, 2002

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article