Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified .gamma.-Fe2O3 nanoparticles towards human tumor cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00493713" target="_blank" >RIV/61389013:_____/18:00493713 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/18:00493713
Result on the web
<a href="http://dx.doi.org/10.3762/bjnano.9.236" target="_blank" >http://dx.doi.org/10.3762/bjnano.9.236</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjnano.9.236" target="_blank" >10.3762/bjnano.9.236</a>
Alternative languages
Result language
angličtina
Original language name
Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified .gamma.-Fe2O3 nanoparticles towards human tumor cells
Original language description
Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal stability in aqueous media and limited internalization by the cells, however, enabled adhesion to the cell surface. While the neat PHPMA-coated particles proved to be non-toxic, doxorubicin-conjugated particles exhibited enhanced cytotoxicity in both drug-sensitive and drug-resistant tumor cells compared to free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/GA17-04918S" target="_blank" >GA17-04918S: Treating Glioblastoma with surface engineered superparamagnetic iron oxide nanoparticles for efficient conjugation with anticancer drugs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Beilstein Journal of Nanotechnology
ISSN
2190-4286
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
25 Sep
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
2533-2545
UT code for WoS article
000446212300001
EID of the result in the Scopus database
2-s2.0-85054059517