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Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified .gamma.-Fe2O3 nanoparticles towards human tumor cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00493713" target="_blank" >RIV/61389013:_____/18:00493713 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/18:00493713

  • Result on the web

    <a href="http://dx.doi.org/10.3762/bjnano.9.236" target="_blank" >http://dx.doi.org/10.3762/bjnano.9.236</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3762/bjnano.9.236" target="_blank" >10.3762/bjnano.9.236</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified .gamma.-Fe2O3 nanoparticles towards human tumor cells

  • Original language description

    Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal stability in aqueous media and limited internalization by the cells, however, enabled adhesion to the cell surface. While the neat PHPMA-coated particles proved to be non-toxic, doxorubicin-conjugated particles exhibited enhanced cytotoxicity in both drug-sensitive and drug-resistant tumor cells compared to free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10404 - Polymer science

Result continuities

  • Project

    <a href="/en/project/GA17-04918S" target="_blank" >GA17-04918S: Treating Glioblastoma with surface engineered superparamagnetic iron oxide nanoparticles for efficient conjugation with anticancer drugs</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Beilstein Journal of Nanotechnology

  • ISSN

    2190-4286

  • e-ISSN

  • Volume of the periodical

    9

  • Issue of the periodical within the volume

    25 Sep

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    13

  • Pages from-to

    2533-2545

  • UT code for WoS article

    000446212300001

  • EID of the result in the Scopus database

    2-s2.0-85054059517