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Expression of CD14 and Toll-Like Receptors on beta-Cells: A Molecular Basis for Innate Anti-beta Cell Immunity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F04%3A00107970" target="_blank" >RIV/61388971:_____/04:00107970 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of CD14 and Toll-Like Receptors on beta-Cells: A Molecular Basis for Innate Anti-beta Cell Immunity

  • Original language description

    Inflammatory mediators such as IL-1beta, TNF-alpha may play a role in the ??cell destruction associated with type 1 diabetes. We have shown that several pattern recognition receptors such as CD14, TLR-2, -3 and -4 are expressed on beta ?cells within islets of Langerhans. We suggest they may be a gateway for innate immune mechanisms in beta-?cell aggression.

  • Czech name

    Exprese CD14 a Toll-podobných receptorů na beta-buňkách: molekulární základ přirozené buněčné imunity proti beta buňkám

  • Czech description

    Mediátory zánětu jako např. IL-1beta, TNF-alfa se mohou podílet na destrukci beta buněk u diabetu 1. typu. Prokázali jsme expresi receptorů CD14, TLR-2, TLR-3 a TLR-4 na beta buňkách Langerhansových ostrůvků. Exprese těchto receptorů na beta buňkách představuje molekulární zaklad pro destrukci beta buněk mechanismy přirozené imunity.

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    International Congress of Immunology /12./

  • ISBN

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

    162

  • Publisher name

  • Place of publication

    Montréal

  • Event location

    Montréal

  • Event date

    Jul 18, 2004

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article