Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F06%3A00053411" target="_blank" >RIV/61388971:_____/06:00053411 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/06:00006514
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Photodynamic treatment (ALA-PDT) suppresses the expression of the oncogenic Bcr-Abl kinase and affects the cytoskeleton organization in K562 cells
Original language description
K562 is the chronic myelogenous leukemia (CML)-derived cell line that expresses high levels of chimeric oncoprotein Bcr-Abl. The deregulated (permanent) kinase activity of Bcr-Abl leads to continuous proliferation of K562 cells and their resistance to the apoptosis promotion by conventional drugs. The photodynamic treatment (PDT) based on the application of 5-aminolevulinic acid (ALA) and irradiation with blue light (ALA-PDT) resulted in the suppression of K562 cells proliferation. It was followed by anecrosis-like cell death. Further on, we observed several changes in the cytoskeleton organization. In connection with this we uncovered certain cytoskeleton organizing proteins involved in the cell response to the treatment
Czech name
Fotodynamická terapie potlačuje expresi onkogenní kinázi Bcr-Abl a má vliv na cytoskeleton buněk K562
Czech description
K562 je buněčná linie odvozená od chronické myeloidní leukémie vykazující vysokou hladinu chimérního onkoproteinu Bcr-Abl. Trvalá kinázová aktivita Bcr-Abl vede k kontinuální proliferaci buněk K562 a jejich resistenci k běžným terepeutikům. Fotodynamickáterapie založená na podání 5-aminolevulové kyseliny a následném ozáření modrým světlem vede k potlačení proliferace buněk K562 s následnou buněčnou smrtí. Současně byly pozorovány změny v organizaci cytoskeletonu této buněčné linie
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NL7681" target="_blank" >NL7681: Exprimental pharmacotherapy of chronic myelogenous leukemia the proteomic approach</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Photochemistry and Photobiology. B - Biology Section
ISSN
1011-1344
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
-
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
205-212
UT code for WoS article
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EID of the result in the Scopus database
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