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Characterization of the NADH:ubiquinone oxidoreductase (complex I) in the trypanosomatid Phytomonas serpens (Kinetoplastida)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F07%3A00087511" target="_blank" >RIV/61388971:_____/07:00087511 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/07:00087511 RIV/60076658:12310/07:00007991

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Characterization of the NADH:ubiquinone oxidoreductase (complex I) in the trypanosomatid Phytomonas serpens (Kinetoplastida)

  • Original language description

    NADH dehydrogenase activity was characterized in the mitochondrial lysates of Phytomonas serpens, a trypanosomatid flagellate parasitizing plants. Two different high molecular weight NADH dehydrogenases were characterized by native PAGE and detected by direct in-gel activity staining. The association of NADH dehydrogenase activities with two distinct multisubunit complexes was revealed in the second dimension performed under denaturing conditions. One subunit present in both complexes cross-reacted withthe antibody against the 39 kDa subunit of bovine complex I. Out of several subunits analyzed by MS, one contained a domain characteristic for the LYR family subunit of the NADH:ubiquinone oxidoreductases. Spectrophotometric measurement of the NADH:ubiquinone 10 and NADH:ferricyanide dehydrogenase activities revealed their different sensitivities to rotenone, piericidin, and diphenyl iodonium.

  • Czech name

    Charakterizace NADH:ubichinon oxidoreduktázy (komplexu I) u trypanosomatida Phytomonas serpens (Kinetoplastida)

  • Czech description

    NADH dehydrogenázová aktivita byla charakterizována v mitochondriálním lyzátu Phytomonas serpens, bičíkatého trypanosomatida parazitujícího rostliny. Dvě odlišné vysokomolekulární NADH dehydrogenázy byly charakterizovány nativní PAGE a detekovány přímýmbarvením aktivity v gelu. Asociace NADH dehydrogenázových aktivit se dvěma různými multipodjednotkovými komplexy byla odhaleny ve druhé dimenzi, provedené za denaturačních podmínek. Jedna podjednotka přítomná v obou komplexech zkříženě reagovala s protilátkou proti 39 kDa podjednotkce kravského komplexu I. Z několika podjednotek analyzovaných MS jedna obsahovala doménu charakteristickou pro rodinu LYR podjednotek NADH:ubichinon oxidoreduktáz. Spektrofotometrické měření NADH:ubichinon 10 a NADH:ferrikyanid dehydrogenázové aktivity odhalilo jejich různou citlivost k rotenonu, piericidinu a diphenyl iodoniu.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FEBS Journal

  • ISSN

    1742-464X

  • e-ISSN

  • Volume of the periodical

    274

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    3150-3158

  • UT code for WoS article

  • EID of the result in the Scopus database