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The effect of weaning on the clonality of alphabeta T- cell receptor T cells in intestine of GF and SPF mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F07%3A00096831" target="_blank" >RIV/61388971:_____/07:00096831 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The effect of weaning on the clonality of alphabeta T- cell receptor T cells in intestine of GF and SPF mice

  • Original language description

    To define the relative effects of bacteria and food antigens in early life, we examined TCR diversity in the intestine SPF and GF mice. In SPF mice the repertoire was polyclonal shortly after birth in the small and large intestine. In contrast, in GF mice the repertoire was oligoclonal after birth, and remained restricted. In SPF conditions, the intestine is seeded with a diverse T ?cell population that becomes oligoclonal around the time weaning: secondly, that GF mice were oligoclonal at each time point

  • Czech name

    Vliv odstavu na vývoj alpha-beta T buněčného receptoru T buněk ve střevě GF a SPF myší

  • Czech description

    Proto, abychom určili podíl střevní mikroflóry a potravních antigenů v imunologickém vývoji střevní tkáně, jsme u myší osazených SPF mikroflórou a u myší bezmikrobních jsme stanovili rozmanitost TCR( T buněčných receptorů).U SPF myší krátce po porodu bylcharakter TCR receptorů polykolnální, krátce po porodu v tenkém i tlustém střevu.Po odstavu zde byly změny k oligoklonálnímu charakteru. Zatímco u GF (bezmikrobních) myší byl tento charakter TCR receptorů oligoklonální po porodu i po odstavu na pevnou dietu

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA303%2F04%2F0849" target="_blank" >GA303/04/0849: Acute and chronic colitis induced by DSS and transfer by CD4+CD45RBhigh T lymphocytes in immunodeficient (SCID) mice: the role of microflora, using probiotics.</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Developmental and Comparative Immunology

  • ISSN

    0145-305X

  • e-ISSN

  • Volume of the periodical

    31

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    606-617

  • UT code for WoS article

  • EID of the result in the Scopus database