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Integrin Subunit CD18 Is the T-Lymphocyte Receptor for the Helicobacter pylori Vacuolating Cytotoxin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F08%3A00099194" target="_blank" >RIV/61388971:_____/08:00099194 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Integrin Subunit CD18 Is the T-Lymphocyte Receptor for the Helicobacter pylori Vacuolating Cytotoxin

  • Original language description

    Helicobacter pylori infection is associated with gastritis, ulcerations, and gastric adenocarcinoma. H. pylori secretes the vacuolating cytotoxin (VacA), a major pathogenicity factor. Here, we show that VacA efficiently enters activated primary human T lymphocytes by binding to the 2 (CD18) integrin receptor subunit

  • Czech name

    Integrinová podjednotka CD18 je T-lymfocytárním receptorem vakuolizačního cytotoxinu bakterie Helicobacter pylori

  • Czech description

    Infekce způsobená bakterií Helicobacter pylori je asociována s gastritidou, tvorbou žaludečních vředů a adenokarcinomem žaludku. H. pylori sekretuje vakuolizační cytotoxin (VacA), který je hlavním faktorem patogenicity. Tato práce ukazuje, že VacA účinněvstupuje do aktivovaných primárních lidských T-lymfocytů díky jeho vazbě k 2 (CD18) integrinové podjednotce

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP204%2F07%2FP105" target="_blank" >GP204/07/P105: Study of the interaction of adenylate cyclase toxin with the integrin receptor CD11b/CD18</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cell Host & Microbe

  • ISSN

    1931-3128

  • e-ISSN

  • Volume of the periodical

    3

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

  • UT code for WoS article

  • EID of the result in the Scopus database