Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00328344" target="_blank" >RIV/61388971:_____/09:00328344 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity

Original language description

Biocatalytic preparation of acylated derivatives of silybin using several acyl donors (free fatty acids or their esters), catalyzed by immobilized Candida antarctica lipase B, was performed in various organic solvents as well as in imidazolium-based ionic liquids containing either BF-4 or PF-6 anions. Total conversion of silybin was achieved in acetone using short-chain acyl donors (vinyl butanoate) at a 10:1 molar ratio of acyl donor to silybin. The enzymatic process in ionic liquids depended stronglyon the alkyl chain length of the cation as well the anion used. Higher conversion yields (up to 75.8 percent) and reaction rates (up to 0.31 mmol h-1 g-1 biocatalyst) were obtained in the BF-4 as compared with PF-6 - containing ionic liquids

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/ME%20922" target="_blank" >ME 922: Enzymatic modification of flavonoids ? preparation of novel hybrid antioxidants with improved antiradical and anti-inflammatory properties</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biocatalysis and Biotransformation

ISSN

1024-2422

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000268032500001

EID of the result in the Scopus database

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