Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F10%3A00348138" target="_blank" >RIV/61388971:_____/10:00348138 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae
Original language description
The human pathogen Streptococcus pneumoniae encodes a single copy of a eukaryotic-like Ser/Thr protein kinase gene designated stkP. Previous studies demonstrated the pleiotropic role of the transmembrane protein kinase StkP in pneumococcal physiology. StkP regulates virulence, competence, and stress resistance and plays a role in the regulation of gene expression. In this study we identified three new substrates of StkP: the Mn-dependent inorganic pyrophosphatase PpaC, the hypothetical protein spr0334,and the cell division protein DivIVA. We showed that StkP activation and substrate recognition depend on the presence of a peptidoglycan-binding domain comprising four PASTA domain repeats. We found that StkP is regulated in a growth-dependent manner andlikely senses intracellular peptidoglycan subunits present in the cell division septa
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Bacteriology
ISSN
0021-9193
e-ISSN
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Volume of the periodical
192
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
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UT code for WoS article
000279183300008
EID of the result in the Scopus database
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