Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F10%3A00354271" target="_blank" >RIV/61388971:_____/10:00354271 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform revealed by hydrogen/deuterium exchange coupled to mass spectrometry
Original language description
Paper describes structural changes of the bovine adenine nucleotide transporter (bAncp). bAncp is an integral membrane protein responsible for the transport of ADP and ATP across the mitochondrial membrane. bAncp can be inhibited by various poisons. We focused on the complex with carboxyatractyloside for which the high-resolution structure is known and with bongkrekic acid for which the mechanism of inhibition remains hidden. Using hydrogen/deuterium exchange coupled to mass spectrometry we showed thateach inhibitor locks the carrier in a different conformation and thus offers unique view on the carrier function
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
—
Volume of the periodical
285
Issue of the periodical within the volume
45
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
—
UT code for WoS article
000283659100072
EID of the result in the Scopus database
—