To suppress to rescue? Changing the approach for recalling anticancer immune responses

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F10%3A00354370" target="_blank" >RIV/61388971:_____/10:00354370 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
To suppress to rescue? Changing the approach for recalling anticancer immune responses
Original language description
The tumor microenvironment plays a fundamental role in influencing the anticancer immune response. Recent experimental anticancer therapy show that some anticancer chemotherapeutics can improve tumor control by acting on immunity and can also be used inimmunosuppressive treatments. On the base of current inflammatory cancer microenvironment model, we suggest recovering the anticancer response by paradoxically inducing a temporary immune suppression. In this paper, we review present concepts about inflammation and immunity in the cancer microenvironment, as well as experimental data from recent literature supporting this paradoxical intervention hypothesis
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/IAA500200917" target="_blank" >IAA500200917: Genetics and immunity in early stages of colorectal adenocarcinoma: inflammatory environment inconventional vs germ-free animal models, and in human samples</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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