Therapeutic potential of the vagus nerve in cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F18%3A00500463" target="_blank" >RIV/61388971:_____/18:00500463 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.imlet.2018.07.006" target="_blank" >http://dx.doi.org/10.1016/j.imlet.2018.07.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.imlet.2018.07.006" target="_blank" >10.1016/j.imlet.2018.07.006</a>

Result language
angličtina
Original language name
Therapeutic potential of the vagus nerve in cancer
Original language description
Accumulating evidence points to a beneficial effect of vagus nerve activity in tumor development. The vagus nerve is proposed to slow tumorigenesis because of its anti-inflammatory properties mediated through ACh and the alpha 7nAChR. Since alpha 7nAChRs are widely expressed by many types of immune cells we hypothesized that the vagus nerve affects the tumor microenvironment and anticancer immunity. We found direct evidence in studies using animal cancer models that vagus nerve stimulation alters immunological responses relevant to the tumor microenvironment. Also studies in pathologies other than cancer suggest a role for the vagus nerve in altering immunological responses relevant to anticancer immunity. These results provide a rationale to expect that vagus nerve stimulation, in combination with conventional cancer treatments, may improve the prognosis of cancer patients by promoting anticancer immunity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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