Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00377903" target="_blank" >RIV/61388971:_____/12:00377903 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1297-9716-43-2" target="_blank" >http://dx.doi.org/10.1186/1297-9716-43-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1297-9716-43-2" target="_blank" >10.1186/1297-9716-43-2</a>

Result language

angličtina

Original language name

Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia

Original language description

Porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae accounts for serious economic losses in the pig farming industry worldwide. We examined here the immunogenicity and protective efficacy of the recombinant type IV fimbrial subunit proteinApfA as a single antigen vaccine against pleuropneumonia, or as a component of a multi-antigen preparation comprising five other recombinant antigens derived from key virulence factors of A. pleuropneumoniae (ApxIA, ApxIIA, ApxIIIA, ApxIVA and TbpB). Immunization of pigs with recombinant ApfA alone induced high levels of specific serum antibodies and provided partial protection against challenge with the heterologous A. pleuropneumoniae serotype 9 strain. This protection was higher than that engenderedby vaccination with rApxIVA or rTbpB alone and similar to that observed after immunization with the tri-antigen combination of rApxIA, rApxIIA and rApxIIIA

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinary Research

ISSN

0928-4249

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

2

Country of publishing house

FR - FRANCE

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000300508600001

EID of the result in the Scopus database

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