The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00379000" target="_blank" >RIV/61388971:_____/12:00379000 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1053/j.gastro.2011.10.038" target="_blank" >http://dx.doi.org/10.1053/j.gastro.2011.10.038</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1053/j.gastro.2011.10.038" target="_blank" >10.1053/j.gastro.2011.10.038</a>
Alternative languages
Result language
angličtina
Original language name
The Copolymer P(HEMA-co-SS) Binds Gluten and Reduces Immune Response in Gluten-Sensitized Mice and Human Tissues
Original language description
Copolymers of hydroxyethyl methacrylate and styrene sulfonate complex with isolated gliadin (the toxic fraction of gluten) and prevent damage to the intestinal barrier in HLA-HCD4/DQ8 mice. We studied the activity toward gluten and hordein digestion andbiologic effects of poly(hydroxyethyl methacrylate-co-styrene sulfonate (P(HEMA-co-SS)). We also investigated the effect of gliadin complex formation in intestinal biopsy specimens from patients with celiac disease. METHODS: We studied the ability of P(HEMA-co-SS) to reduce digestion of wheat gluten and barley hordein into immunotoxic peptides using liquid chromatography-mass spectrometry
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA310%2F07%2F0414" target="_blank" >GA310/07/0414: The role of innate and adaptive immunity in development of gluten-sensitive entheropathy</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology
ISSN
0016-5085
e-ISSN
—
Volume of the periodical
142
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
316-325
UT code for WoS article
000299540000038
EID of the result in the Scopus database
—