Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00379960" target="_blank" >RIV/61388971:_____/12:00379960 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/12:00379960
Result on the web
<a href="http://dx.doi.org/10.1039/c2sm26150b" target="_blank" >http://dx.doi.org/10.1039/c2sm26150b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c2sm26150b" target="_blank" >10.1039/c2sm26150b</a>
Alternative languages
Result language
angličtina
Original language name
Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system
Original language description
The surface modification of nanoparticles by physically anchoring hydrophilic biocompatible polymers is a simple and commercially attractive strategy to produce stealth drug delivery nanocarriers. Herein, we report the preparation, characterization and preliminary evaluation of the biological behaviour of polymeric nanoparticles (NPs) comprising a biodegradable poly(butylene succinate-co-butylene dilinoleate) ? PBS/PBDL ? copolyester and a non-immunogenic and non-toxic hydrophilic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer. Narrowly distributed sub-100 nm polymeric nanoparticles with stealth properties were successfully prepared by using a combination of interfacial nanoprecipitation and self-assembly. The assemblies were characterized by usingcomplementary scattering techniques and cryo-transmission electron microscopy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Soft Matter
ISSN
1744-683X
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
37
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
9563-9575
UT code for WoS article
000308095700010
EID of the result in the Scopus database
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