Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual-Responsive Shell as Biomedical Platforms for Controlled Release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315414" target="_blank" >RIV/00216208:11310/15:10315414 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/macp.201500235" target="_blank" >http://dx.doi.org/10.1002/macp.201500235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/macp.201500235" target="_blank" >10.1002/macp.201500235</a>
Alternative languages
Result language
angličtina
Original language name
Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual-Responsive Shell as Biomedical Platforms for Controlled Release
Original language description
Multifunctional polymeric platforms combining (bio)degradable and biocompatible, temperature and pH-sensitive entities hold great promise as nanocarriers for targeted drug and gene delivery, and tissue engineering. In this work, preparation and characterization of surfactant-free polyester nanoparticles (NPs) from biobased polyesters poly(butylene sebacate) (PBSE) and poly(butylene sebacate-co-butylene dilinoleate)s (PBSE/PBDL) using nanoprecipitation is reported. This strategy leads to spherical nanosized particles with sizes narrowly distributed in a range of 30-200 nm which is appropriate for internalization by a variety of cells. The effect of molecular parameters and type of solvent used in the nanoprecipitation protocol on the size and shape of produced polyester nanocolloids and their in vitro degradation in PBS solution at 37 degrees C is elucidated by quasi-elastic light scattering (QELS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and size-exclusio
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Chemistry and Physics
ISSN
1022-1352
e-ISSN
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Volume of the periodical
216
Issue of the periodical within the volume
23
Country of publishing house
DE - GERMANY
Number of pages
15
Pages from-to
2287-2301
UT code for WoS article
000366391600007
EID of the result in the Scopus database
2-s2.0-84949536216