Structural changes on polymeric nanoparticles induced by hydrophobic drug entrapment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F18%3A00481177" target="_blank" >RIV/61389013:_____/18:00481177 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.colsurfa.2017.10.059" target="_blank" >http://dx.doi.org/10.1016/j.colsurfa.2017.10.059</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfa.2017.10.059" target="_blank" >10.1016/j.colsurfa.2017.10.059</a>
Alternative languages
Result language
angličtina
Original language name
Structural changes on polymeric nanoparticles induced by hydrophobic drug entrapment
Original language description
The potential use of polyester polymeric nanoparticles (NPs) as drug nanocarriers is well-documented. Nevertheless, structural changes due to hydrophobic drug loading and release have been rarely explored. Herein, we have used static and dynamic light scattering (SDLS), small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM) and cryo-TEM to probe how the entrapment of a hydrophobic drug molecule changes the nanoparticles feature. The presence of the hydrophobic drug molecule modifies the inner structure of the NPs. The polymeric assemblies are characterized by differences in their densities (proximately 0.06 g cm-3 for poly(D,L-lactide) - PLA or poly(D,L-lactide-co-glycolide - PLGA) and 0.46 g cm-3 for poly[(butylene succinate)-co-(butylene dilinoleate)] - PBSBDL). They are thus water swollen in the drug-free condition. The NPs were further prepared by using the same polyesters and given amounts of the poorly water-soluble drug paclitaxel (PTX). The density (dNP), RG (radius of gyration), RH (hydrodynamic radius), RG/RH and R (contrast radius) have been monitored as a function of the amount of drug loaded. The drug entrapment increased the size of PLA and PLGA NPs. On the other hand, it also promoted the shrinkage of PBSBDL NPs. These observations revealed that changes in the inner structure of soft nanoparticles caused by drug loading is not straightforward and it mainly depends on the strength of van der Waals interactions between the polyester core and the probe which is connected to their chemical composition and hydrophobicity. These findings are crucial to understand the key physicochemical parameters involved in the interactions between drug and polymer that affects the final particle structure and influence its loading, release and degradation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces. A - Physicochemical and Engineering Aspects
ISSN
0927-7757
e-ISSN
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Volume of the periodical
538
Issue of the periodical within the volume
5 February
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
238-249
UT code for WoS article
000418586600029
EID of the result in the Scopus database
2-s2.0-85033217557