Antibody repertoire development in fetal and neonatal piglets. XXII. lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00386940" target="_blank" >RIV/61388971:_____/12:00386940 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/j.1365-2567.2012.03615.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-2567.2012.03615.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1365-2567.2012.03615.x" target="_blank" >10.1111/j.1365-2567.2012.03615.x</a>

Result language

angličtina

Original language name

Antibody repertoire development in fetal and neonatal piglets. XXII. lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine

Original language description

VDJ and VJ rearrangements, expression of RAG-1, Tdt and VpreB, and the presence of signal joint circles (SJC) were used to identify sites of B-cell lymphogenesis. VDJ, V?J? but not V?J? rearrangements or SJC were recovered from yolk sac (YS) at 20 similar to days of gestation (DG) along with strong expression of VpreB and RAG-1 but weak Tdt expression. V?J? rearrangements but not V?J? rearrangements were recovered from fetal liver at 3050 DG. SJC were pronounced in bone marrow at 95 DG where V?J? rearrangements were first recovered. The V?J? rearrangements recovered at 2050 DG used some of the same V? and J? segments seen in older fetuses and adult animals. Hence the textbook paradigm for the order of light-chain rearrangement does not apply to swine.Consistent with weak Tdt expression in early sites of lymphogenesis, N-region additions in VDJ rearrangements were more frequent at 95 DG. Junctional diversity in V?J? rearrangement was limited at all stages of development. There was litt

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunology

ISSN

0019-2805

e-ISSN

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Volume of the periodical

137

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

149-159

UT code for WoS article

000308405700005

EID of the result in the Scopus database

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