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T cells in swine completely rearrange immunoglobulin heavy chain genes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00517717" target="_blank" >RIV/61388971:_____/19:00517717 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0145305X19301491?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0145305X19301491?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.dci.2019.103396" target="_blank" >10.1016/j.dci.2019.103396</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    T cells in swine completely rearrange immunoglobulin heavy chain genes

  • Original language description

    Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJ(H) genes. The first population can be found exclusively in medulla and it consists of existing mature B cells and plasma cells. The second consists of developing B cells characterized by the presence of selected VDJ(H )rearrangement, similar to B cell lymphogenesis in the bone marrow. The third population is entirely unaffected by selection mechanism for productive VDJ(H )rearrangement and represents T lineage cells that rearrange immunoglobulin genes. Transcription of unselected VDJ(H) repertoire is not allowed in T cells. Sequence analysis of unselected VDJ(H) repertoire from T cells also revealed important consequences for B cell lymphogenesis and selection of B cell repertoire. As far as we know, this is the first evidence that some species completely rearrange VDJ(H )genes in T cells. Our results also support the finding that B cells actively develop in the thymus.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10613 - Zoology

Result continuities

  • Project

    <a href="/en/project/GA16-09296S" target="_blank" >GA16-09296S: What cells are responsible for unselected B cell repertoire in the porcine thymus?</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Developmental and Comparative Immunology

  • ISSN

    0145-305X

  • e-ISSN

  • Volume of the periodical

    99

  • Issue of the periodical within the volume

    OCT 2019

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    UNSP 103396

  • UT code for WoS article

    000477690500009

  • EID of the result in the Scopus database

    2-s2.0-85066431008