T cells in swine completely rearrange immunoglobulin heavy chain genes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00517717" target="_blank" >RIV/61388971:_____/19:00517717 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0145305X19301491?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0145305X19301491?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2019.103396" target="_blank" >10.1016/j.dci.2019.103396</a>
Alternative languages
Result language
angličtina
Original language name
T cells in swine completely rearrange immunoglobulin heavy chain genes
Original language description
Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJ(H) genes. The first population can be found exclusively in medulla and it consists of existing mature B cells and plasma cells. The second consists of developing B cells characterized by the presence of selected VDJ(H )rearrangement, similar to B cell lymphogenesis in the bone marrow. The third population is entirely unaffected by selection mechanism for productive VDJ(H )rearrangement and represents T lineage cells that rearrange immunoglobulin genes. Transcription of unselected VDJ(H) repertoire is not allowed in T cells. Sequence analysis of unselected VDJ(H) repertoire from T cells also revealed important consequences for B cell lymphogenesis and selection of B cell repertoire. As far as we know, this is the first evidence that some species completely rearrange VDJ(H )genes in T cells. Our results also support the finding that B cells actively develop in the thymus.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology
Result continuities
Project
<a href="/en/project/GA16-09296S" target="_blank" >GA16-09296S: What cells are responsible for unselected B cell repertoire in the porcine thymus?</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental and Comparative Immunology
ISSN
0145-305X
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
OCT 2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
UNSP 103396
UT code for WoS article
000477690500009
EID of the result in the Scopus database
2-s2.0-85066431008