Polymer therapeutics with a coiled coil motif targeted against murine BCL1 leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00390945" target="_blank" >RIV/61388971:_____/13:00390945 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/13:00390945 RIV/68378050:_____/13:00390945

Result on the web

<a href="http://dx.doi.org/10.1021/bm3019592" target="_blank" >http://dx.doi.org/10.1021/bm3019592</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/bm3019592" target="_blank" >10.1021/bm3019592</a>

Result language

angličtina

Original language name

Polymer therapeutics with a coiled coil motif targeted against murine BCL1 leukemia

Original language description

The specificity of polymer conjugates based on N-(2-hydroxypropyl)methacrylamide (HPMA) bearing cytostatic drugs for cancer cells could be significantly increased by the incorporation of a suitable targeting ligand, such as a monoclonal antibody (mAb). However, direct binding of the protein to the polymer carrier could cause considerable problems, such as decreasing the binding capacity of mAb to its target. Here, we introduce a novel strategy of joining a targeting moiety to a polymeric conjugate withcytostatic drug. The scFv of B1 mAb (specific for BCL1 leukemia cells) was tagged with peptide K ((VAALKEK)4). Peptide E ((VAALEKE)4), which forms a stable coiled coil structure heterodimer with peptide K, was assembled with the HPMA copolymers bearing doxorubicin. Such targeted polymeric conjugates possess very selective and high binding activity toward BCL1 cells. Similarly, targeted polymeric conjugates exert approximately 100 times higher cytostatic activity toward BCL1 cells in comp

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomacromolecules

ISSN

1525-7797

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

881-889

UT code for WoS article

000316044700034

EID of the result in the Scopus database

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