Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00392590" target="_blank" >RIV/61388971:_____/13:00392590 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.molcatb.2012.10.004" target="_blank" >http://dx.doi.org/10.1016/j.molcatb.2012.10.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.molcatb.2012.10.004" target="_blank" >10.1016/j.molcatb.2012.10.004</a>

Result language

angličtina

Original language name

Biotransformation of codeine to 14-OH-codeine derivatives by Rhizobium radiobacter R89-1

Original language description

A Gram-negative bacterium transforming codeine 1a to 14-hydroxycodeine 1c was isolated from the sample of composted wastes of Papaver somniferum deposited in a factory producing poppy seed. Based on 16S ribosomal RNA gene phylogeny, biochemical and morphological properties, the strain was designated as Rhizobium radiobacter R89-1. The bacterium is able to transform 1a into four C-14-hydroxy derivatives of codeine. When used as a whole-cell catalyst, 100% conversion was achieved at concentration of 1a upto 6.0 g/L to 14-hydroxycodeine 1c as a single product. Biohydroxylation of codeine to C-14-hydroxy derivatives, a high tolerance of the strain to 1a and activity with morphine 2a make the biocatalyst promising for pharmaceutical applications. (c) 2012Elsevier B.V. All rights reserved

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/2B08064" target="_blank" >2B08064: Introduction of producers generating new and modified antibiotics.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Molecular Catalysis B-Enzymatic

ISSN

1381-1177

e-ISSN

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Volume of the periodical

87

Issue of the periodical within the volume

MAR 2013

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

1-5

UT code for WoS article

000314012900001

EID of the result in the Scopus database

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