Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147715" target="_blank" >RIV/61989592:15310/13:33147715 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201300701" target="_blank" >http://dx.doi.org/10.1002/ejoc.201300701</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201300701" target="_blank" >10.1002/ejoc.201300701</a>

Result language
angličtina
Original language name
Synthesis of 1-Aminocodeine as a Synthon for Other Codeine Derivatives
Original language description
The first nitration of codeine by using bismuth nitrate pentahydrate under mild reaction conditions is described. The resulting 1-nitrocodeine was reduced to 1-aminocodeine, a key precursor for the synthesis of the azo derivative and several hydrazones.Structures of both 1-nitrocodeine and 1-amino-codeine were unequivocally determined by single-crystal Xray analysis. The reported preliminary synthetic study lays the groundwork for the synthesis of modified codeine derivatives with potential biologicalactivity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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