Beta-N-Acetylhexosaminidases: group-specific inhibitors wanted
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00395482" target="_blank" >RIV/61388971:_____/13:00395482 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/9781849737173-00102" target="_blank" >http://dx.doi.org/10.1039/9781849737173-00102</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/9781849737173-00102" target="_blank" >10.1039/9781849737173-00102</a>
Alternative languages
Result language
angličtina
Original language name
Beta-N-Acetylhexosaminidases: group-specific inhibitors wanted
Original language description
Beta-N-Acetylhexosaminidases (GH20) and ?-N-acetylglucosaminidases (GH84) are two genetically and functionally unrelated classes of glycosidases sharing the substrate-assisted catalytic mechanism and architecture of their active sites. In humans, the deficiency of these enzymes causes severe neurodegenerative disorders (GH20) and Alzheimer?s disease (GH84). For the research of the physiological functions of these enzymes, inhibitors selective for just one of the enzyme families must be employed in orderto avoid the generation of complex phenotypes. The search for highly potent and selective inhibitor sis based on the known common and distinct features of these enzyme groups, profiting from the crystal structures of the enzyme-inhibitor complexes. In this chapter, the most studied inhibitor scaffolds such as NAG-thiazoline, PUGNAc and GlcNAcstatins and their rationally designed analogues are described and discussed, providing an actual survey of the most efficient and selective compoun
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP13-06818P" target="_blank" >GP13-06818P: New synthetic approaches using mutant and wild-type beta-N-acetylhexosaminidase from Talaromyces flavus</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Carbohydrate Chemistry
ISBN
978-1-84973-587-2
Number of pages of the result
18
Pages from-to
102-119
Number of pages of the book
246
Publisher name
The Royal Society of Chemistry
Place of publication
Cambridge
UT code for WoS chapter
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