Inhibition of microbial ?-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00435534" target="_blank" >RIV/61388971:_____/14:00435534 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Inhibition of microbial ?-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline
Original language description
NAG-thiazoline is a well-established competitive inhibitor of two physiologically relevant glycosidase families??-N-acetylhexosaminidases (GH20) and ?-N-acetylglucosaminidases (GH84). Based on the different substrate flexibilities of these enzyme groups,we designed and synthesized the 4-deoxy derivative of NAG-thiazoline aiming at the selective inhibition of GH20 ?-N-acetylhexosaminidases. One GH84 and two GH20 microbial glycosidases were employed as model enzymes for the inhibition assays. Surprisingly, the new compound 4-deoxy-thiazoline exhibited no activity inhibition with either of the enzyme families of interest. Unlike with the substrates, the 4-hydroxyl group of the inhibitor?s sugar ring seems to be crucial for binding the inhibitor to the active sites of these enzymes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894X
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
22
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
5321-5323
UT code for WoS article
000343901400039
EID of the result in the Scopus database
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