Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00421945" target="_blank" >RIV/61388971:_____/13:00421945 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/13:00421945
Result on the web
<a href="http://dx.doi.org/10.1093/jxb/ert271" target="_blank" >http://dx.doi.org/10.1093/jxb/ert271</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jxb/ert271" target="_blank" >10.1093/jxb/ert271</a>
Alternative languages
Result language
angličtina
Original language name
Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells
Original language description
TPX2 performs multiple roles in microtubule organization. Previously, it was shown that plant AtTPX2 binds AtAurora1 kinase and colocalizes with microtubules in a cell cycle-specific manner. To elucidate the function of TPX2 further, this work analysed Arabidopsis cells overexpressing AtTPX2-GFP. Distinct arrays of bundled microtubules, decorated with AtTPX2-GFP, were formed in the vicinity of the nuclear envelope and in the nuclei of overexpressing cells. The microtubular arrays showed reduced sensitivity to anti-microtubular drugs. TPX2-mediated formation of nuclear/perinuclear microtubular arrays was not specific for the transition to mitosis and occurred independently of Aurora kinase. The fibres were not observed in cells with detectable programmed cell death and, in this respect, they differed from TPX2-dependent microtubular assemblies functioning in mammalian apoptosis. Colocalization and co-purification data confirmed the interaction of importin with AtTPX2-GFP. In cells with
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Experimental Botany
ISSN
0022-0957
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
14
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
4575-4587
UT code for WoS article
000326724700034
EID of the result in the Scopus database
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