Neonatal colonization of germ-free mice with Bifidobacterium longum prevents allergic sensitization to major birch pollen allergen Bet v 1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00422117" target="_blank" >RIV/61388971:_____/13:00422117 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.vaccine.2013.09.014" target="_blank" >http://dx.doi.org/10.1016/j.vaccine.2013.09.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.vaccine.2013.09.014" target="_blank" >10.1016/j.vaccine.2013.09.014</a>

Result language

angličtina

Original language name

Neonatal colonization of germ-free mice with Bifidobacterium longum prevents allergic sensitization to major birch pollen allergen Bet v 1

Original language description

The main goal in reversing the allergy epidemic is the development of effective prophylactic strategies. We investigated the prophylactic effect of neonatal mother-to-offspring mono-colonization with Bifidobacterium longum ssp. longum CCM 7952 on subsequent allergic sensitization. Adult male and female germ-free (GF) mice were mono-colonized with B. longum, mated and their offspring, as well as age-matched GF controls, were sensitized with the major birch pollen allergen Bet v 1. Furthermore, signalingpathways involved in the recognition of B. longum were investigated in vitro. Neonatal mono-colonization of GF mice with B. longum suppressed Bet v 1-specific IgE-dependent beta-hexosaminidase release as well as levels of total IgE and allergen-specificIgG2a in serum compared to sensitized GF controls. Accordingly, Bet v 1-induced production of both Thl- and Th2-associated cytokines in spleen cell cultures was significantly reduced in these mice. The general suppression of Bet v 1-speci

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Vaccine

ISSN

0264-410X

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

46

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

5405-5412

UT code for WoS article

000327173000014

EID of the result in the Scopus database

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