Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F11%3A00375208" target="_blank" >RIV/61388971:_____/11:00375208 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Neonatal colonization of mice with probiotic bacteria: Impact on systemic sensitization to aeroallergen Bet v 1

Original language description

Mono-colonization of mice with the Bet v 1 producing L. plantarum induced a Th1-biased immune response at the cellular level and reduced levels of Bet v 1 specific antibodies in sera, while wild type strain had no such effect. On the other hand, B. longum strain supressed cytokine production as well as specific antibody production. In vitro we showed different immunomodulatory properties of these two strains with different signalling through TLR receptors. We speculate that strong Th1 inducers like L. plantarum are able to modulate the systemic sensitization in vivo only when administrated together with the allergen. On the other hand, moderately stimulating probiotics such as B. longum ssp. longum are able to suppress the sensitization in a differentway by inducing Treg bias

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů