Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00428380" target="_blank" >RIV/61388971:_____/14:00428380 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/14:33149006

Result on the web

<a href="http://dx.doi.org/10.3390/molecules19044115" target="_blank" >http://dx.doi.org/10.3390/molecules19044115</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules19044115" target="_blank" >10.3390/molecules19044115</a>

Result language

angličtina

Original language name

Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers

Original language description

Divalent or multivalent molecules often show enhanced biological aktivity relative to the simple monomeric units. Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by in situ and ex situ square wave voltammetry. The oxidation of monomers and dimers was similar, but adsorption onto the electrode and cell surfaces was different. A 1,1-diphenyl-2-picrylhydrazyl (DPPH) and an inhibition of microsomallipoperoxidation assay were performed with same trend of results for silybin and 2,3-dehydrosilybin dimers. Silybin dimer showed better activity than the monomer, while on the contrary 2,3- dehydrosilybin dimer presented weaker antioxidant/antilipoperoxidant activity than its monomer. Cytotoxicity was evaluated on human umbilical vein endothelial cells, normal human adult keratinocytes, mouse fibroblasts (BALB/c 3T3) and human liver hepatocellular carcinoma cell line (HepG2). Silybin dim

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

4115-4134

UT code for WoS article

000336087800018

EID of the result in the Scopus database

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