Phototoxic potential of silymarin and its bioactive components

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00460043" target="_blank" >RIV/61388971:_____/16:00460043 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/16:33159003 RIV/00098892:_____/16:N0000009

Result on the web

<a href="http://dx.doi.org/10.1016/j.jphotobiol.2016.01.011" target="_blank" >http://dx.doi.org/10.1016/j.jphotobiol.2016.01.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jphotobiol.2016.01.011" target="_blank" >10.1016/j.jphotobiol.2016.01.011</a>

Result language

angličtina

Original language name

Phototoxic potential of silymarin and its bioactive components

Original language description

Silymarin, a standardized extract of the seeds of the milk thistle (Silybum marianum) and its major component, silybin, is now used as an active component in a broad spectrum of dietary supplements, cosmetics and dermatological preparations. However, despite its use in skin products, there are no published data to exclude its phototoxic potential. The primary purpose of this study was to examine the phototoxicity of silymarin and its flavonolignans, silybin, isosilybin, silychristin, silydianin and 2,3-dehydrosilybin by validated 3T3 NRU assay. Further, we compared the validated biological system Balc/c 3T3 cell line with other cell models, particularly normal human dermal fibroblasts (NHDF), normal human epidermal keratinocytes (NHEK) and the human keratinocyte cell line (HaCaT). The results showed that silymarin and the flavonolignans silybin, isosilybin, silychristin and silydianin had no phototoxicity towards any of the cells used. In contrast, 2,3-dehydrosilybin was identified as a compound with phototoxic potential. Further study is needed to evaluate the health risks associated with 2,3-dehydrosilybin use in skin preparations

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

<a href="/en/project/GA15-10897S" target="_blank" >GA15-10897S: Modulation of human skin cell responses to UVA radiation by silymarin components</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Photochemistry and Photobiology. B - Biology Section

ISSN

1011-1344

e-ISSN

—

Volume of the periodical

156

Issue of the periodical within the volume

MAR 2016

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

61-68

UT code for WoS article

000371951500009

EID of the result in the Scopus database

2-s2.0-84956939137