2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00510260" target="_blank" >RIV/61388971:_____/19:00510260 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2504-3900/11/1/21" target="_blank" >https://www.mdpi.com/2504-3900/11/1/21</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/proceedings2019011021" target="_blank" >10.3390/proceedings2019011021</a>

Result language
angličtina
Original language name
2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases
Original language description
Silybum marianum fruit extract silymarin displays various biological activities, which are attributed mostly to its major component silybin. However, silymarin contain several other isomeric flavonolignans (isosilybin, silychristin, silydianin) and their oxidation products, the 2,3-dehydroflavonolignans (2,3-dehydrosilybin, 2,3-dehydrosilychristin, 2,3-dehydrosilydianin). The latter compounds were found to be 1-2 orders of magnitude more efficient radical scavengers, reducing, chelating, cytoprotective, anti-aging, anti-cancer and anti-angiogenic agents than the parent flavonolignans. Although 2,3-dehydroflavonolignans occur in silymarin as minorities, they seem to be responsible for the majority of the biological activity and therefore have potential for the prevention of chronic diseases.
Czech name
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Czech description
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Project
<a href="/en/project/GA18-00132S" target="_blank" >GA18-00132S: Inter-individual variability in the metabolism of silymarin flavonolignans in humans</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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