Silybin and its congeners: from traditional medicine to molecular effects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00558662" target="_blank" >RIV/61388971:_____/22:00558662 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2022/NP/D2NP00013J" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/NP/D2NP00013J</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d2np00013j" target="_blank" >10.1039/d2np00013j</a>
Alternative languages
Result language
angličtina
Original language name
Silybin and its congeners: from traditional medicine to molecular effects
Original language description
Covering: 2015 up to 2022 (Feb) Silymarin, an extract of milk thistle (Silybum marianum) fruits, has been used in various medicinal applications since ancient times. A major component of silymarin is the flavonolignan silybin and its relatives isosilybin, silychristin, silydianin, 2,3-dehydrosilybin, and some others. Except for silydianin, they occur in nature as two stereomers. This review focuses on recent developments in chemistry, biosynthesis, modern advanced analytical methods, and transformations of flavonolignans specifically reflecting their chirality. Recently described chemotypes of S. marianum, but also the newest findings regarding the pharmacokinetics, hepatoprotective, antiviral, neuroprotective, and cardioprotective activity, modulation of endocrine functions, modulation of multidrug resistance, and safety of flavonolignans are discussed. A growing number of studies show that the respective diastereomers of flavonolignans have significantly different activities in anisotropic biological systems. Moreover, it is now clear that flavonolignans do not act as antioxidants in vivo, but as specific ligands of biological targets and therefore their chirality is crucial. Many controversies often arise, mainly due to the non-standard composition of this phytopreparation, the use of various undefined mixtures, the misattribution of silymarin vs. silybin, and also the failure to consider the chemistry of the respective components of silymarin.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Natural Product Reports
ISSN
0265-0568
e-ISSN
1460-4752
Volume of the periodical
39
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
1264-1281
UT code for WoS article
000790828700001
EID of the result in the Scopus database
2-s2.0-85133101119