Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00547159" target="_blank" >RIV/61388971:_____/21:00547159 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/15/7885" target="_blank" >https://www.mdpi.com/1422-0067/22/15/7885</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22157885" target="_blank" >10.3390/ijms22157885</a>
Alternative languages
Result language
angličtina
Original language name
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
Original language description
This review focuses on the specific biological effects of optically pure silymarin flavo-nolignans, mainly silybins A and B, isosilybins A and B, silychristins A and B, and their 2,3-dehydro derivatives. The chirality of these flavonolignans is also discussed in terms of their analysis, preparative separation and chemical reactions. We demonstrated the specific activities of the respective diastereomers of flavonolignans and also the enantiomers of their 2,3-dehydro derivatives in the 3D anisotropic systems typically represented by biological systems. In vivo, silymarin flavonolignans do not act as redox antioxidants, but they play a role as specific ligands of biological targets, according to the ´lock-and-key´ concept. Estrogenic, antidiabetic, anticancer, antiviral, and antiparasitic effects have been demonstrated in optically pure flavonolignans. Potential application of pure flavonolignans has also been shown in cardiovascular and neurological diseases. Inhibition of drug-metabolizing enzymes and modulation of multidrug resistance activity by these compounds are discussed in detail. The future of ´silymarin applications´ lies in the use of optically pure components that can be applied directly or used as valuable lead structures, and in the exploration of their true molecular effects.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA21-01799S" target="_blank" >GA21-01799S: Flavonoids as a unique class of carbon monoxide photoreleasable molecules</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
22
Issue of the periodical within the volume
15
Country of publishing house
CH - SWITZERLAND
Number of pages
45
Pages from-to
7885
UT code for WoS article
000681819700001
EID of the result in the Scopus database
2-s2.0-85110756423