Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10134161" target="_blank" >RIV/00216208:11310/13:10134161 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/13:00395308
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetlet.2012.11.049" target="_blank" >http://dx.doi.org/10.1016/j.tetlet.2012.11.049</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetlet.2012.11.049" target="_blank" >10.1016/j.tetlet.2012.11.049</a>

Result language
angličtina
Original language name
Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives
Original language description
The base-catalyzed oxidation of the flavonolignans, silybin, and isosilybin into the corresponding 2,3-dehydro derivatives has been studied and optimized. Various bases, solvents, and reaction conditions were tested to achieve the best yields. The influence of water on the course of the reaction was also observed. It was found that this oxidation reaction was probably based on the disproportionation of the (iso)silybin (or some intermediate) molecule, as the reaction also proceeds in the absence of oxygen. We report here for the first time the preparation of optically pure 2,3-dehydroisosilybins A and B.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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