Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223141" target="_blank" >RIV/61989592:15110/11:10223141 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/11:00370938 RIV/61989592:15310/11:10223141

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

Original language description

Flavonolignans, silybin and its derivatives and isosilybin were studied using ex situ C Vand SWV. The two oxidation steps were described for flavonolignans at potentials Ep1 +0.5 V and Ep2 +0.85 V. Oxidation peak at Ep3 +0.35 V was observed only for 2,3-dehydrosilybin. Results confirmed that 2,3-dehydrosilybin is a relatively strong antioxidant, which is strictly associated with oxidation at Ep3. Antioxidant parameters of flavonolignans can be affected by transition metal complexation via hydroxyl groups. Silybin and 2,3-dehydrosilybin are able to chelate transition metals, especially Cu2+. The electrochemical investigation of DNA interactions and damage caused in the presence of silybin/Cu complex and hydrogen peroxide is described. We present evidence that flavonolignans are involved not only in antioxidant abilities but also in the prooxidation effects under in vitro conditions.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioelectrochemistry

ISSN

1567-5394

e-ISSN

—

Volume of the periodical

82

Issue of the periodical within the volume

2

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

117-124

UT code for WoS article

—

EID of the result in the Scopus database

—