Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00507891" target="_blank" >RIV/61388971:_____/19:00507891 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/19:43918907

Result on the web

<a href="https://www.mdpi.com/2076-3921/8/7/236" target="_blank" >https://www.mdpi.com/2076-3921/8/7/236</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/antiox8070236" target="_blank" >10.3390/antiox8070236</a>

Result language

angličtina

Original language name

Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties

Original language description

Antioxidants protect the structural and functional components in organisms against oxidative stress. Most antioxidants are of plant origin as the plants are permanently exposed to oxidative stress (UV radiation, photosynthetic reactions). Both carotenoids and flavonoids are prominent antioxidant and anti-radical agents often occurring together in the plant tissues and acting in lipophilic and hydrophilic milieu, respectively. They are complementary in their anti-radical activity. This study describes the synthesis of a series of hybrid ester conjugates of retinoic acid with various flavonolignans, such as silybin, 2,3-dehydrosilybin and isosilybin. Antioxidant/anti-radical activities and bio-physical properties of novel covalent carotenoid-flavonoid hybrids, as well as various mixtures of the respective parent components, were investigated. Retinoyl conjugates with silybin-which is the most important flavonolignan in silymarin complex-(and its pure diastereomers) displayed better 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than both the parent compounds and their equimolar mixtures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10401 - Organic chemistry

Project

<a href="/en/project/LTC17009" target="_blank" >LTC17009: Carotenoids and flavonoids: interactions and hybrid antioxidants</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ANTIOXIDANTS

ISSN

2076-3921

e-ISSN

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Volume of the periodical

8

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

12

Pages from-to

236

UT code for WoS article

000478608600020

EID of the result in the Scopus database

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