Interaction of isolated silymarin flavonolignans with iron and copper
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F18%3A10381908" target="_blank" >RIV/00216208:11160/18:10381908 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/18:00497478
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S016201341830285X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S016201341830285X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2018.09.006" target="_blank" >10.1016/j.jinorgbio.2018.09.006</a>
Alternative languages
Result language
angličtina
Original language name
Interaction of isolated silymarin flavonolignans with iron and copper
Original language description
Silymarin (the standardized extract of mainly flavonolignans from silybum marianum) is approved for the adjuvant therapy of alcoholic liver disease and is also sold as an over the counter drug for miscelaneous purposes. Hence, the exposition of humans to these flavonolignans is not negligible. In this study we tested the interaction of isolated optically pure flavonolignans from silymarin with iron and copper which is relevant in the gastrointestinal tract due to low biovailability of these compounds. Only 2,3-dehydrosilybin was found to be a potent or moderately active iron and copper chelator. Silybin A, silybin B and silychristin A were less potent or inactive chelators. Both 2,3-dehydrosilybin enantiomers (A and B) were equally active iron and copper chelators, and the preferred stoichiometries were mainly 2:1 and 3:1 (2,3-dehydrosilybin:metal). Additional experiments showed that silychristin was the most potent iron and copper reductant.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA18-00121S" target="_blank" >GA18-00121S: The role of optically pure flavonolignans in cardiovascular effects of silymarin</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Inorganic Biochemistry
ISSN
0162-0134
e-ISSN
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Volume of the periodical
189
Issue of the periodical within the volume
December
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
115-123
UT code for WoS article
000449036800012
EID of the result in the Scopus database
2-s2.0-85053810495