Access to bifunctionalized biomolecular platforms using oxime ligation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00432688" target="_blank" >RIV/61388971:_____/14:00432688 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.carres.2014.04.020" target="_blank" >http://dx.doi.org/10.1016/j.carres.2014.04.020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carres.2014.04.020" target="_blank" >10.1016/j.carres.2014.04.020</a>

Result language
angličtina
Original language name
Access to bifunctionalized biomolecular platforms using oxime ligation
Original language description
This paper describes an efficient oxime ligation strategy to prepare multivalent conjugates wherein peptides alone or in combination with carbohydrate or oxime groups were coupled to a cyclopeptide scaffold. To demonstrate the versatility of this approach, two classes of conjugates have been prepared. In one class, we attached two or four peptide sequences to the cyclopeptide core together with free oxime groups, while the second class contains an additional substitution with four or two monosaccharides. The well-defined structure of these conjugates was confirmed by high-resolution mass spectrometry
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/LD13042" target="_blank" >LD13042: Enzymatic synthesis of multivalent glycoconjugates of natural and biologically active compounds.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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