Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00433022" target="_blank" >RIV/61388971:_____/14:00433022 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jbm.a.34873" target="_blank" >http://dx.doi.org/10.1002/jbm.a.34873</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.a.34873" target="_blank" >10.1002/jbm.a.34873</a>
Alternative languages
Result language
angličtina
Original language name
Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine
Original language description
Immunocompatibility of gelatin-based hydrogels to be applied as implant coatings for local regenerative treatment has been studied. First, the bio- and immuno-acceptability of the methacrylamide-modified gelatin hydrogels per se was screened. The resultsindicated that the hydrogels support cell growth. Metabolic activity of normal cells and permanent cell lines representing various cell types (endothelial, epithelial, fibroblast, and monocyte/macrophage) cultivated on the gelatin hydrogels was moderately lower compared to cells cultivated on tissue culture plastic. The cells cultivated on the hydrogels produced identical cytokines as the control cells although at lower levels. Importantly, no inflammatory activity, measured by nitric oxide and pro-inflammatory cytokine (IL-1, IL-6, and TNF) production, was observed in peritoneal cells and monocyte/macrophage RAW 264.7 cell line cultivated on the hydrogels
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP301%2F12%2F1254" target="_blank" >GAP301/12/1254: Overcoming Natural and Multidrug Resistance by Tumor-Selective Delivery of ABC Transporter/Bcl-2 Inhibitors or Therapeutic Gene under PEG-3 Promoter</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biomedical Materials Research. Part A
ISSN
1549-3296
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1982-1990
UT code for WoS article
000334488800036
EID of the result in the Scopus database
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