Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00433507" target="_blank" >RIV/61388971:_____/14:00433507 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s12026-014-8549-5" target="_blank" >http://dx.doi.org/10.1007/s12026-014-8549-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12026-014-8549-5" target="_blank" >10.1007/s12026-014-8549-5</a>

Result language

angličtina

Original language name

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic

Original language description

Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that especially affects neonates within the "critical window" of immunological development. PRRS was recognized in 1987 and within a few years became pandemic causing an estimated yearly $600,000 economic loss in the USA with comparative losses in most other countries. The causative agent is a single-stranded, positive-sense enveloped arterivirus (PRRSV) that infects macrophages and plasmacytoid dendritic cells. Despite thediscovery of PRRSV in 1991 and the publication of > 2,000 articles, the control of PRRS is problematic. Despite the large volume of literature on this disease, the cellular and molecular mechanisms describing how PRRSV dysregulates the host immune system are poorly understood. We know that PRRSV suppresses innate immunity and causes abnormal B cell proliferation and repertoire development, often lymphopenia and thymic atrophy. The PRRSV genome is highly diverse, rapidly evolving but ame

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunologic Research

ISSN

0257-277X

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

1-3

Country of publishing house

US - UNITED STATES

Number of pages

28

Pages from-to

81-108

UT code for WoS article

000340369900010

EID of the result in the Scopus database

—