Stroma as an Active Player in the Development of the Tumor Microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00436418" target="_blank" >RIV/61388971:_____/14:00436418 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/15:00506403

Result on the web

<a href="http://dx.doi.org/10.1007/s12307-014-0150-x" target="_blank" >http://dx.doi.org/10.1007/s12307-014-0150-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12307-014-0150-x" target="_blank" >10.1007/s12307-014-0150-x</a>

Result language

angličtina

Original language name

Stroma as an Active Player in the Development of the Tumor Microenvironment

Original language description

The stroma is a considerable part of the tumor microenvironment. Because of its complexity, it can influence both cancer and immune cells in their behavior and cross-talk. Aside from soluble products released by non-cancer and cancer cells, extracellular matrix components have been increasingly recognized as more thanjust minor players in the constitution, development and regulation of the tumor microenvironment. The variations in the connective scaffold architecture, inducedby transforming growth factor beta, lysyl oxidase and metalloproteinase activity,create different conditions of ECM density and stiffness. They exert broad effects on immune cells (e.g. physical barriers, modulation by release of stored TGF-β1), mesenchymal cells (transition to myofibroblasts), epithelial cells (epithelial-to-mesenchymal transition), cancer cells (progression to metastatic phenotype) and stem cells (activation of differentiation addressed by the microenvironment characteristics). Physiological mechanisms of the wound healing process, as well as mechanisms of fibrosis in some chronic pathologies, closelyrecall aspects of cancer deregulated biology.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Microenvironment

ISSN

1875-2292

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

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UT code for WoS article

000219520000003

EID of the result in the Scopus database

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