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Hydrolysis of Nitriles to Carboxylic Acids

Result description

The biocatalytic hydrolysis of nitriles to carboxylic acids is catalyzed by either a nitrilase or a bienzymatic cascade system comprised of a nitrile hydratase and an amidase. Using the same enzymes, amides can be obtained as side products (by nitrilases) or as intermediates (by nitrile hydratases). The tendency to form amides is characteristic of some nitrilases and depends also on the substrate structure, a bulky or an electrophilic group enhancing the turnover of nitrile into amide.

Keywords

nitrilasenitrile hydrataseamidase

The result's identifiers

Alternative languages

  • Result language

    angličtina

  • Original language name

    Hydrolysis of Nitriles to Carboxylic Acids

  • Original language description

    The biocatalytic hydrolysis of nitriles to carboxylic acids is catalyzed by either a nitrilase or a bienzymatic cascade system comprised of a nitrile hydratase and an amidase. Using the same enzymes, amides can be obtained as side products (by nitrilases) or as intermediates (by nitrile hydratases). The tendency to form amides is characteristic of some nitrilases and depends also on the substrate structure, a bulky or an electrophilic group enhancing the turnover of nitrile into amide.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Science of Synthesis

  • ISBN

    978-3-13-174131-8

  • Number of pages of the result

    26

  • Pages from-to

    277-302

  • Number of pages of the book

    610

  • Publisher name

    Georg Thieme Verlag KG Stuttgart

  • Place of publication

    Stuttgart

  • UT code for WoS chapter

Basic information

Result type

C - Chapter in a specialist book

C

CEP

CE - Biochemistry

Year of implementation

2015