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PVA immunonanofibers with controlled decay

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00453203" target="_blank" >RIV/61388971:_____/15:00453203 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/15:00453203

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.polymer.2015.09.018" target="_blank" >http://dx.doi.org/10.1016/j.polymer.2015.09.018</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.polymer.2015.09.018" target="_blank" >10.1016/j.polymer.2015.09.018</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    PVA immunonanofibers with controlled decay

  • Original language description

    Nanofibers are utilized in crucial biomedical applications owing to their unique properties, including an enormous surface-to-volume ratio. Here, we report the biofunctionalization of polyvinyl alcohol (PVA) nanofibers by specific antibodies. This approach is built on regulated acylation of PVA nanofibers by polyethylene glycol with biotin (PEG-b) linker and sequence-specific binding of avidin-antibody conjugate. We have successfully demonstrated a chemically modified PVA-PEG-b, where the modification by the PEG-b linker resulted in the altered decay of nanofibers. Additionally, our studies on two different models indicate that the bound avidin-antibody conjugate was active. The first model was based on the binding of transferrin to immobilized anti-transferrin, and the second system was based on the recognition and binding of beta 1 integrin localized on mesenchymal stem cells resulting in their improved adhesion to PVA-PEG-b nanofibers. Our findings suggest that this is a versatile m

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polymer Journal

  • ISSN

    0032-3896

  • e-ISSN

  • Volume of the periodical

    77

  • Issue of the periodical within the volume

    Oct 23

  • Country of publishing house

    JP - JAPAN

  • Number of pages

    12

  • Pages from-to

    387-398

  • UT code for WoS article

    000363484300045

  • EID of the result in the Scopus database

    2-s2.0-84945485649