PVA immunonanofibers with controlled decay

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00453203" target="_blank" >RIV/61388971:_____/15:00453203 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00453203

Result on the web

<a href="http://dx.doi.org/10.1016/j.polymer.2015.09.018" target="_blank" >http://dx.doi.org/10.1016/j.polymer.2015.09.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.polymer.2015.09.018" target="_blank" >10.1016/j.polymer.2015.09.018</a>

Result language

angličtina

Original language name

PVA immunonanofibers with controlled decay

Original language description

Nanofibers are utilized in crucial biomedical applications owing to their unique properties, including an enormous surface-to-volume ratio. Here, we report the biofunctionalization of polyvinyl alcohol (PVA) nanofibers by specific antibodies. This approach is built on regulated acylation of PVA nanofibers by polyethylene glycol with biotin (PEG-b) linker and sequence-specific binding of avidin-antibody conjugate. We have successfully demonstrated a chemically modified PVA-PEG-b, where the modification by the PEG-b linker resulted in the altered decay of nanofibers. Additionally, our studies on two different models indicate that the bound avidin-antibody conjugate was active. The first model was based on the binding of transferrin to immobilized anti-transferrin, and the second system was based on the recognition and binding of beta 1 integrin localized on mesenchymal stem cells resulting in their improved adhesion to PVA-PEG-b nanofibers. Our findings suggest that this is a versatile m

Czech name

—

Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymer Journal

ISSN

0032-3896

e-ISSN

—

Volume of the periodical

77

Issue of the periodical within the volume

Oct 23

Country of publishing house

JP - JAPAN

Number of pages

12

Pages from-to

387-398

UT code for WoS article

000363484300045

EID of the result in the Scopus database

2-s2.0-84945485649