PVA Immunonanofibers with Controlled Decay
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F15%3A00240400" target="_blank" >RIV/68407700:21460/15:00240400 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21720/15:00240400 RIV/00216208:11130/15:10315697 RIV/61989592:15310/15:33156140 RIV/61989592:15110/15:33156140
Result on the web
<a href="http://dx.doi.org/10.1016/j.polymer.2015.09.018" target="_blank" >http://dx.doi.org/10.1016/j.polymer.2015.09.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.polymer.2015.09.018" target="_blank" >10.1016/j.polymer.2015.09.018</a>
Alternative languages
Result language
angličtina
Original language name
PVA Immunonanofibers with Controlled Decay
Original language description
Nanofibers are utilized in crucial biomedical applications owing to their unique properties, including an enormous surface-to-volume ratio. Here, we report the biofunctionalization of polyvinyl alcohol (PVA) nanofibers by specific antibodies. This approach is built on regulated acylation of PVA nanofibers by polyethylene glycol with biotin (PEG-b) linker and sequence-specific binding of avidin–antibody conjugate. We have successfully demonstrated a chemically modified PVA-PEG-b, where the modification by the PEG-b linker resulted in the altered decay of nanofibers. Additionally, our studies on two different models indicate that the bound avidin–antibody conjugate was active. The first model was based on the binding of transferrin to immobilized anti-transferrin, and the second system was based on the recognition and binding of β1 integrin localized on mesenchymal stem cells resulting in their improved adhesion to PVA-PEG-b nanofibers. Our findings suggest that this is a versatile model for the preparation of PVA-based immuno-nanofibers whose decay can be controlled.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polymer
ISSN
0032-3861
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
October
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
387-398
UT code for WoS article
000363484300045
EID of the result in the Scopus database
2-s2.0-84945485649