Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00456525" target="_blank" >RIV/61388971:_____/15:00456525 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/15:00457062 RIV/67985904:_____/15:00456525

Result on the web

<a href="http://dx.doi.org/10.1186/s13099-015-0080-2" target="_blank" >http://dx.doi.org/10.1186/s13099-015-0080-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13099-015-0080-2" target="_blank" >10.1186/s13099-015-0080-2</a>

Result language

angličtina

Original language name

Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis

Original language description

None of the HMA mice developed colitis spontaneously. When treated with DSS, mice in F4 generation of one line of colonized mice (aHMA) developed colitis. Compared to the DSS-resistant earlier generations of aHMA mice, the F4 generation have increased abundance of Clostridium difficile and decrease abundance of C. symbiosum in their cecum contents measured by denaturing gradient gel electrophoresis and DNA sequencing. In our study, mucosa-associated microbes of UC patients were not able to induce spontaneous colitis in gnotobiotic BALB/c mice but they were able to increase the susceptibility to DSS-induced colitis, once the potentially deleterious microbes found a suitable niche.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gut Pathogens

ISSN

1757-4749

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

32

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

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UT code for WoS article

000367148700001

EID of the result in the Scopus database

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