Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00460046" target="_blank" >RIV/61388971:_____/16:00460046 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/16:00059635
Result on the web
<a href="http://dx.doi.org/10.1016/j.imlet.2015.11.010" target="_blank" >http://dx.doi.org/10.1016/j.imlet.2015.11.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.imlet.2015.11.010" target="_blank" >10.1016/j.imlet.2015.11.010</a>
Alternative languages
Result language
angličtina
Original language name
Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes
Original language description
Macrolide antibiotics such as azithromycin or clarithromycin are known to have potent anti-inflammatory and immunomodulatory effects but these properties cannot be widely used due to a risk of bacterial resistance. We studied another polyketide antibiotic, structurally related manumycin A known as a streptomycete derived farnesyltransferase inhibitor with limited antibacterial effects, with respect to its potential regulation of mRNA expression of several genes associated with proinflammatory responses. Downregulation of mRNA for IL-6, TLR-8, IL-1 beta and IL-10 was found in THP-1 cells after 4 h stimulation with TNF alpha in the presence of manumycin A and downregulated TLR-8 and EGR-1 genes were observed after 8 h. Among the genes upregulated in response to manumycin were HMOX-1, TNFRSF10A, IL-1R1, TICAM2, NLRP12 after 4 h and only IL-1R1 after 8 h.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Immunology Letters
ISSN
0165-2478
e-ISSN
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Volume of the periodical
169
Issue of the periodical within the volume
JAN 2016
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
8-14
UT code for WoS article
000369205200002
EID of the result in the Scopus database
2-s2.0-84947903541