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cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00462060" target="_blank" >RIV/61388971:_____/16:00462060 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/cmi.12519" target="_blank" >http://dx.doi.org/10.1111/cmi.12519</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/cmi.12519" target="_blank" >10.1111/cmi.12519</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes

  • Original language description

    The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) plays a key role in virulence of Bordetella pertussis. CyaA penetrates myeloid cells expressing the complement receptor 3 ((M2) integrin CD11b/CD18) and subverts bactericidal capacities of neutrophils and macrophages by catalysing unregulated conversion of cytosolic ATP to the key signalling molecule adenosine 3',5'-cyclic monophosphate (cAMP). We show that the signalling of CyaA-produced cAMP hijacks, by an as yet unknown mechanism, the activity of the tyrosine phosphatase SHP-1 and activates the pro-apoptotic BimEL-Bax cascade. Mitochondrial hyperpolarization occurred in human THP-1 macrophages within 10min of exposure to low CyaA concentrations (e.g. 20ngml(-1)) and was accompanied by accumulation of BimEL and association of the pro-apoptotic factor Bax with mitochondria.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cellular Microbiology

  • ISSN

    1462-5814

  • e-ISSN

  • Volume of the periodical

    18

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    384-398

  • UT code for WoS article

    000370643500007

  • EID of the result in the Scopus database

    2-s2.0-84958102950